KPTI SCHEDULE 13G/A: SEC filing

Affinity Asset Advisors, LLC and Michael Cho

Filed with the SEC on Nov 13, 2026 · accession 0001011438-26-000695

KPTI filed a SCHEDULE 13G/A (schedule 13g/a) with the SEC on Nov 13, 2026. Affinity Asset Advisors, LLC and Michael Cho filed an amended Schedule 13G reporting beneficial ownership of 1,573,517 shares (6.5%) of Karyopharm Therapeutics common stock, held via warrants subject to a 9.99% beneficial ownership limitation.

Summary of the filing

Affinity Asset Advisors, LLC and Michael Cho filed an amended Schedule 13G reporting beneficial ownership of 1,573,517 shares (6.5%) of Karyopharm Therapeutics common stock, held via warrants subject to a 9.99% beneficial ownership limitation. The filing is a passive institutional ownership disclosure with no stated intent to influence control.

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Key details

Shares of common stock beneficially owned (issuable upon exercise of warrants)$1.6M

Percent of common stock outstanding beneficially owned$7

Total shares of common stock outstanding (as of August 6, 2026)$24.3M

Reporting person / investment managerAffinity Asset Advisors, LLC

Direct holder of the securitiesAffinity Healthcare Fund, LP

IssuerKaryopharm Therapeutics Inc.

Managing member of affinity asset advisors, llcMichael Cho

Chief financial officer and chief compliance officer of affinity asset advisors, llcAndrew Weinstein

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Frequently asked questions

What did KPTI file with the SEC on Nov 13, 2026?

KPTI filed a SCHEDULE 13G/A (SEC filing). Affinity Asset Advisors, LLC and Michael Cho filed an amended Schedule 13G reporting beneficial ownership of 1,573,517 shares (6.5%) of Karyopharm Therapeutics common stock, held via warrants subject to a 9.99% beneficial ownership limitation. The filing is a passive institutional ownership disclosure with no stated intent to influence control.

How do I read a SCHEDULE 13G/A?

A report the company filed with the SEC (the US market regulator). Start with the summary, then the key amounts and names. Compare it with the company’s earlier filings.

Why are SEC filings important?

Public companies must tell the SEC about anything that can change their value — results, leadership changes, big deals, new shares, bankruptcy. Filings are the official source, often before the news. A SCHEDULE 13G/A (schedule 13g/a): A report the company filed with the SEC (the US market regulator).

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