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SYRE 424B5: Secondary offering

Spyre Therapeutics

Filed with the SEC on · accession 0001628280-26-065249

SYRE filed a 424B5 (prospectus (offering)) with the SEC on Oct 6, 2026. Spyre Therapeutics filed a 424B5 prospectus supplement under its existing S-3 shelf registration, indicating a securities offering. The stock moved -13.6% by the first close after the filing.

Summary of the filing

Spyre Therapeutics filed a 424B5 prospectus supplement under its existing S-3 shelf registration, indicating a securities offering. The filing text contains only XBRL cover-page metadata with no pricing or share details.

For details, click here →How to read a 424B5 →

Key details

IssuerSpyre Therapeutics, Inc.

How SYRE stock reacted

Close before

$92.72

Oct 5, 2026

First close after

-13.60%

$80.11

5 trading days

-7.36%

$85.90

Since filing

+12.01%

$103.86

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Frequently asked questions

What did SYRE file with the SEC on Oct 6, 2026?

SYRE filed a 424B5 (Secondary offering). Spyre Therapeutics filed a 424B5 prospectus supplement under its existing S-3 shelf registration, indicating a securities offering. The filing text contains only XBRL cover-page metadata with no pricing or share details.

What does a secondary offering mean for SYRE stock?

New shares dilute existing holders and are often sold at a discount to the market price.

How do I read a 424B5?

The final terms of an offering of shares or bonds. Look at price, number of shares and the discount to the market price. Large offerings dilute existing shareholders.

Why are SEC filings important?

Public companies must tell the SEC about anything that can change their value — results, leadership changes, big deals, new shares, bankruptcy. Filings are the official source, often before the news. A 424B5 (prospectus (offering)): The final terms of an offering of shares or bonds.

How did SYRE stock react to this filing?

SYRE closed at $92.72 before the filing and $80.11 on Oct 6, 2026 (-13.60%). Five trading days later: $85.90 (-7.36%).

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