SEPTInvestingStart Free

SYRE 424B5: Secondary offering

Spyre Therapeutics, Inc.

Filed with the SEC on · accession 0001628280-26-064924

SYRE filed a 424B5 (prospectus (offering)) with the SEC on Oct 5, 2026. Spyre Therapeutics, Inc. filed a preliminary prospectus supplement (424B5) for an underwritten public offering of common stock, with an underwriters' option to purchase additional shares. The stock moved -0.5% by the first close after the filing.

Summary of the filing

Spyre Therapeutics, Inc. filed a preliminary prospectus supplement (424B5) for an underwritten public offering of common stock, with an underwriters' option to purchase additional shares. The offering price and share count are left blank pending completion.

For details, click here →How to read a 424B5 →

Key details

Last reported sale price per share on October 2, 2026$93
Joint book-running managerJefferies
Joint book-running managerTD Cowen
Joint book-running managerLeerink Partners
Joint book-running managerStifel
Passive bookrunnerLifeSci Capital

How SYRE stock reacted

Close before

$93.19

Oct 2, 2026

First close after

-0.50%

$92.72

5 trading days

-8.05%

$85.69

Since filing

+11.45%

$103.86

✦ Ask GOAX AI about this filing — what it means for SYRE, what changed since its last filings and what to watch next.

Try it free for 7 days

🔔 Want to stay updated on new SEC filings for SYRE?

Click here

Frequently asked questions

What did SYRE file with the SEC on Oct 5, 2026?

SYRE filed a 424B5 (Secondary offering). Spyre Therapeutics, Inc. filed a preliminary prospectus supplement (424B5) for an underwritten public offering of common stock, with an underwriters' option to purchase additional shares. The offering price and share count are left blank pending completion.

What does a secondary offering mean for SYRE stock?

New shares dilute existing holders and are often sold at a discount to the market price.

How do I read a 424B5?

The final terms of an offering of shares or bonds. Look at price, number of shares and the discount to the market price. Large offerings dilute existing shareholders.

Why are SEC filings important?

Public companies must tell the SEC about anything that can change their value — results, leadership changes, big deals, new shares, bankruptcy. Filings are the official source, often before the news. A 424B5 (prospectus (offering)): The final terms of an offering of shares or bonds.

How did SYRE stock react to this filing?

SYRE closed at $93.19 before the filing and $92.72 on Oct 5, 2026 (-0.50%). Five trading days later: $85.69 (-8.05%).

Other SYRE SEC filings

Get alerts when SYRE files with the SEC, plus live charts, key levels and news for 13,000+ stocks.

Try SEPT free for 7 days
SYRE overviewSYRE analysisSYRE newsLatest SEC filings